Rafael Holdings, Inc. is a holding company. The Company owns interests in clinical and early-stage pharmaceutical companies and commercial real estate assets. The Company is focused on the discovery of cancer and immune metabolism therapeutics. The Company operates through two segments: Pharmaceuticals and Real Estate. The Pharmaceuticals segment is comprised of preferred and common equity interests and the Warrant to purchase equity interests in Rafael Pharmaceuticals, a majority equity interest in LipoMedix, Barer, Levco, Farber and Rafael Medical Devices. The Real Estate segment consists of the Company’s real estate holdings associated with a portion of an office building in Israel.